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Dear Mark, great, that's what I figured. Thanks a lot for the quick response! Best wishes, Katharina On Sat, 15 Mar 2014 09:14:09 +0000 Mark Jenkinson <[log in to unmask]> wrote: > Dear Katharina, > > You don't have to worry about this - the dual regression >technique takes care of it by performing regressions >(spatial and then temporal) to estimate the >subject-specific timecourses and spatial maps, rather >than simple averages. So it takes into account the sign >of the connectivities. > > All the best, > Mark > > > On 14 Mar 2014, at 17:46, Katharina Bey ><[log in to unmask]> wrote: > >> Dear FSL experts, >> >> I ran MELODIC + dual regression to estimate the average >>time series of each component for each subject (stage 1 >>outputs). I want to use these for further analyses. Now >>I'm wondering how exactly the individual time series are >>estimated. Some of my components contain negative as well >>as positive connections. So if the stage 1 outputs are >>generated by averaging time series within each component >>(as I have read in a few papers), won't this lead to >>faulty results if there are positive and negative >>connections? I guess that "averaging" might just be wrong >>terminology here and the negative connections are somehow >>accounted for. Still, I want to make sure because this >>might explain some of my results. >> >> Thanks a lot for your help! >> >> Best, >> Katharina