Dear Donald, Helmut, Chris, Marko and all,
The discussion is really inspiring and interesting. Apart
from cluster size setting concern, shall we also talk about if
there's a widely accepted series of procedures to carry out
SVC by SPM? We came across with initial p thresholding, and
voxel vs cluster SVC. Are there any literature out there
giving some answers to such field? I think it's crucial to
come up with a standardized procedures to perform SVC (as well
as standardized way to report) so as to reduce
misunderstanding. SPM8 manual only got a paragraph with three
lines or something which surely looks rather thin and abstract
for beginners like me.
And a major point raised here which worths further
discussion is: biological reality. We've been talking FWE 0.05
as a statistical cut-off point for distinguishing
significance. I strongly agree that the surviving voxels can
be noise or just tip of an iceberg. In our current days, how
is the acceptance for the ideas of more liberal FWE threshold/
FDR threshold/ uncorrected p threshold but with cluster size
threshold? Matthew Brett suggested the ideas of more liberal
threshold or unthresholded SPM reporting to explore and
display the possibility of a bigger, if not whole, picture of
brain activation. (
https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=spm;664eed4.05)
But that was 9 years ago already. Are there any changes in the
mainstream thoughts?
Best,
Andy