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Hi On 10 Feb 2014, at 13:27, Antoinette Nicolle <[log in to unmask]> wrote: > Dear FSL experts, > > I'm running TBSS on DTI data from a sample of participants that have an age range of 12-25 years (mean about 18 yrs). They're all healthy participants, and so I don't really have one "most typical" participant. > > When using tbss_2_reg would it be best to just use the FMRIB58_FA as the target image? Yes - that's probably the best option - though you could try the non-default "most typical subject" option too, in case you're concerned about bias... Cheers. > As I understand it, this template was based on participants with a somewhat higher mean age than 18 yrs. Would it be best to generate a study-specific template and, if so, is there a standard procedure for this? > > Many thanks in advance, > Antoinette --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve --------------------------------------------------------------------------- Stop the cultural destruction of Tibet