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From: SPM (Statistical Parametric Mapping) [[log in to unmask]] on behalf of Kapse, Kushal Janardan [[log in to unmask]]
Sent: Wednesday, January 08, 2014 8:56 AM
To: [log in to unmask]
Subject: Re: [SPM] Activation on skull

Hi Donald,

I checked the EPI to T1 registration. Seems the top few slices of the EPI brain is getting chopped. No issues with T1. This happens in the step of normalization. I checked the slicetiming, realigned files and they looked. Its in mean realigned image and thereafter which seems to cutoff the top brain. I have attached a word file which has a axial/sagittal   snapshot of the EPI image. If you can take a look and give me a feedback of possible ways this issue happening, that would be helpful.


Thanks

Kushal J Kapse

Aphasia Research Laboratory
Boston University

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From: MCLAREN, Donald [[log in to unmask]]
Sent: Tuesday, January 07, 2014 5:14 PM
To: Kapse, Kushal Janardan
Subject: Re: [SPM] Activation on skull

Have you checked the EPI to T1 registration? If its not properly registered, could this be the source of activation in the skull?

Best Regards, Donald McLaren
=================
D.G. McLaren, Ph.D.
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Postdoctoral Research Fellow, GRECC, Bedford VA
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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On Tue, Jan 7, 2014 at 5:08 PM, Kushal Kapse <[log in to unmask]<mailto:[log in to unmask]>> wrote:
Hi SPM users,

I am analyzing data for stroke patient and we have been having issue for two of our patients with abnormal activation maps. There is large amount of activation on the skull and area between skull and gray matter. I have been reading and have been trying to change various parameters in SPM to find a solution for this issue, but havent been successful yet. Hence, i thought of sharing this with SPM users expecting a suggestion which might help me solve this problem.


Also, following pipeline was used to analyze the data

Slice timing
Realign Est & Reslice
Coreg- estimate (ref imge-mean resliced function; source image- T1, other image-masked image)
Segment
Normalise:write (T1 image)
Normalise:write
Smooth

GLM
units of design-secs
Canonical HRF
No derivatives
Classical estimation

Please provide me a thought on where i need to expect changes or source of these abnormal activations


Thanks
Kushal