This is a very common analysis. You setup the two-sample t-test and add your covariates.

See the following cite on interpreting the results: mumford.fmripower.org/mean_centering/

Best Regards, Donald McLaren
=================
D.G. McLaren, Ph.D.
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Postdoctoral Research Fellow, GRECC, Bedford VA
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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On Mon, Jan 27, 2014 at 2:56 PM, Jidan Zhong <[log in to unmask]> wrote:
Hi

I have a question about doing group comparison between healthy control and patients. I wonder do you know whether i can do two-sample t-test with the 2 groups with covariates of age and gender?
I don't know whether it makes sense by controlling for age and gender and then do the 2-sample t test, as I never came across any papers did this. Anyone got any idea? Thanks! 

--
Regards,

Jidan