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Dear experts,


I'm working on a data set in which two anatomical volumes were acquired on the same day. Previously I would have went with realign to create a mean, which I then would have forwarded to segmentation.

Now I would like to try the longitudinal registration in SPM12b. It seems the two volumes undergo bias correction independently (?) before an average volume is created, which seems to be preferable to me. However, I'm not sure how to limit the registration to proper rigid transformations (can this be specified with warping regularisation parameters, and if so, which values? Should bias regularisation be kept with the default 1,000,000?).

I would then like to segment the average volume. Should I adjust the parameters for bias regularaisation?


Thank you!

Helmut