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Dear all, I am wondering how to perform mixed effect analysis in SPM (probably a dumb question). For example, I have 100 subjects (50 for group A, and 50 for group B), each subject has 8 sessions. For each session, we can derive a fMRI measure, e.g., degree centrality. I am assuming within subject (8 sessions) should be a fixed effect analysis, and then between subjects (50 vs. 50) should be a random effect analysis? How can I compare the two groups of degree centrality with a mixed effect analysis then? How can I set it up in SPM? Or I should simply average the 8 sessions for each subject, and then perform a two-sample t-test on the averages between the two groups? Thanks a lot! Best, Chao-Gan -- Chao-Gan YAN, Ph.D. Research Scientist The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962 Research Assistant Professor Department of Child and Adolescent Psychiatry / NYU Langone Medical Center Child Study Center, New York University, New York, NY 10016 - Initiating + Service Node The R-fMRI Network (RFMRI.ORG) http://rfmri.org/yan http://scholar.google.com/citations?user=lJQ9B58AAAAJ&hl=en