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Hi

In general, combining different protocols is not recommended. But if your aimed contrasts are orthogonal to protocol type, then you may be able to combine the data. (for instance for a group difference where the groups are distributed equally in both protocols).

Your TR difference is unlikely to cause major differences, as T1 recovery should have had sufficient time to take place.

You don’t need to resample the data, the TBSS pipeline will do it for you.

Cheers

Saad

Dear Experts,

I have read the previous posts about this topic, but none discussed voxel size or TR differences. Both acquisitions are on a GE scanner as follows:

Sequence 1:

b=1000
directions = 25 + 1 b0
matrix = 128x128
FOV= 240x240
slices = 46
slice thickness = 3.0
TR=12400

Sequence 2:

b=1000
directions= 25 + 2b0
matrix = 128x128
FOV= 330x330
slices = 52
slice thickness = 2.4
TR= 14000

I was wondering if: 1. I can combine these datasets. and 2. Do I need to resample the data to a common voxel size.

Thank you and Happy New Year!

Alex