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Hi, I would use the GUI to create the appropriate fsf file, and this will contain the filename where the list of PNM regressors can be found (the filename that is entered into the GUI). You can then edit this fsf file to point at different files for different datasets. In this way you can avoid using the FEAT GUI after the first initial setup. I would definitely recommend doing it like this and not trying to create the fsf file from scratch, as the latter is very difficult to get right. All the best, Mark On 10 Jan 2014, at 16:28, Xue Zhang <[log in to unmask]<mailto:[log in to unmask]>> wrote: Dear experts, I'm using Pnm to do physiological noise correction, so far I can generate physiological regressors for GLM, but I found I can only use these regressors in GUI FEAT,which is not convenient for huge data processing. I tried to write these regressors in my fsf template, but the regressors disappeared after I re-opened the template. I'm wondering whether Pnm is really only used in GUI, I have a pretty large number of data to be analyzed, anyone knowns how to use Pnm regressor in GLM more easier and not in GUI? Regards Xue -- 张雪，博士生 清华大学 生物医学工程系 生物医学影像研究中心 北京（海淀区）清华大学生物医学影像研究中心201室 邮编 100084 Xue Zhang, Ph.D candidate Center for Biomedical Imaging Research, Department of Biomedical Engineering #201, Center for Biomedical Imaging Research, Tsinghua University 100084