Sorry for perhaps a "silly" question I had a question in regards to using MELODIC ICA for denoising of my functional data. I ran it once, deemed what components were acceptable and which were not visually, and denoised my filtered.func.data using fsl_regfilt. However, I decided to run melodic once again on my denoised data just for my own interest. The number of estimated components decreased, but I still found a couple components to be "noise" label worthy.

I was just wondering if there was any use to run Melodic more than once for ICA denoising? From what I've gathered, I don't recall ever once seeing a mention of MELODIC being run more than once for ICA denoising. I'm assuming there's a reason NOT TO since like I mentioned, I never seen it mentioned, but was curious if there would be any benefits.