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Dear Andy, for Powerpoint and other MS programs 300 ppi should be the maximum (actually 307 ppi I think), although this requires some adjustments. See PLOS guidelines for details http://www.plosone.org/static/figureGuidelines#size and also Microsoft support at http://support.microsoft.com/default.aspx?scid=kb;en-us;827745 Best, Helmut