You need to make sure the the origin is at the AC and the rotation matches the MNI template. If you are using the T1 segmentation parameters for normalization, then you need to make sure that the T1 and fMRI data are co-registered.

Best Regards, Donald McLaren
=================
D.G. McLaren, Ph.D.
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Postdoctoral Research Fellow, GRECC, Bedford VA
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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On Thu, Dec 5, 2013 at 2:54 PM, Lei Gao <[log in to unmask]> wrote:

Dear SPM experts,

     I encountered a very tricky problem, I processed the fMRI data with SPM8, including format convert, slice timing, head motion correction spatial normalization to the Montreal Neurological Institute (MNI) template (resampling voxel size = 3¡Á3¡Á3 mm3), unfortunately, I found the functional volumes can't be normalized (both EPI template and T1 segement).  I want to know where may be wrong and the possible solutions. thanks in advance!

                                                                                                                                 Lei.