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Hi - on the basis of T1-weighted images it’s not easy to get a really accurate estimate of ICV - partly because both CSF and skull are dark. If you look at T2 data (or e.g. T1 and T2 combined - e.g. with betsurf) you can get closer. Cheers. On 16 Dec 2013, at 08:09, Olof Lindberg <[log in to unmask]> wrote: > Dear FSL experts > > I want to get a number for intracranial volume. I know that Sienax output a scaling factor that i principle could be used for normalizing volumetric data etc. > However I would also prefer to get a real number for the ICV - can I use the scaling factor and multiply it by the volume of the template? And in that case do we know what is the volume of the template? > > > an explanation would be greatly appreciated. > > Regards > Olof Lindberg --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve --------------------------------------------------------------------------- Stop the cultural destruction of Tibet