Dear Dr Smith Could you provide the way about how to use betsurf to get more reliable ICV measurement ? I couldn't find any manual for this script tool and wish to use it to measure ICV data. Best Paul Date: Mon, 16 Dec 2013 08:23:03 +0000 From: [log in to unmask] Subject: Re: [FSL] Intracranial volume To: [log in to unmask] Hi - on the basis of T1-weighted images it¡¦s not easy to get a really accurate estimate of ICV - partly because both CSF and skull are dark. If you look at T2 data (or e.g. T1 and T2 combined - e.g. with betsurf) you can get closer. Cheers. On 16 Dec 2013, at 08:09, Olof Lindberg <[log in to unmask]> wrote:Dear FSL experts I want to get a number for intracranial volume. I know that Sienax output a scaling factor that i principle could be used for normalizing volumetric data etc. However I would also prefer to get a real number for the ICV - can I use the scaling factor and multiply it by the volume of the template? And in that case do we know what is the volume of the template? an explanation would be greatly appreciated. Regards Olof Lindberg --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve --------------------------------------------------------------------------- Stop the cultural destruction of Tibet