I am currently using the longitudinal registration tool from SPM 12 in order to estimate GM volumes changes between 2 time points and relate these changes to clinical measures.Once I created the Jacobian difference image, I understood I should multiply the volume differences image by the GM volumes but I can't get how.1/ Which GM volume shall I choose (Time 1 or the mid point average) ?
2/ Shall I use the total GM volume or voxel by voxel ?
3/ Which tool shall I use to do this in SPM ?