For those of you trying out the Longitudinal toolbox in SPM12, here's something that you may wish to look out for.
"Although neurogenesis or atrophy certainly occurs, the use
of T1-weighted scans to identify change in brain structure
in vivo in humans has vulnerability: the T1 relaxation time
for arterial blood and gray matter are not clearly distin-
guishable and therefore, apparent reported structural find-
ings might be at least partially related to changes in blood
flow or other physiological signals."
Franklin, Teresa R., Ze
Wang, Joshua Shin, Kanchana Jagannathan, Jesse J. Suh, John A. Detre,
Charles P. O’Brien, and Anna Rose Childress. "A VBM study demonstrating
‘apparent’effects of a single dose of medication on T1-weighted MRIs." Brain Structure and Function 218, no. 1 (2013): 97-104.
Best regards,
-John
