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For those of you trying out the Longitudinal toolbox in SPM12, here's something that you may wish to look out for. *"Although neurogenesis or atrophy certainly occurs, the useof T1-weighted scans to identify change in brain structurein vivo in humans has vulnerability: the T1 relaxation timefor arterial blood and gray matter are not clearly distin-guishable and therefore, apparent reported structural find-ings might be at least partially related to changes in bloodflow or other physiological signals."* Franklin, Teresa R., Ze Wang, Joshua Shin, Kanchana Jagannathan, Jesse J. Suh, John A. Detre, Charles P. O’Brien, and Anna Rose Childress. "A VBM study demonstrating ‘apparent’effects of a single dose of medication on T1-weighted MRIs." *Brain Structure and Function* 218, no. 1 (2013): 97-104. Best regards, -John