Dear all, our endocrinologists have a patient who has arranged private genetic testing for polymorphisms in the DIO2 (diodinase) gene. She is apparently now quite insistent that she should be started on T3 despite being biochemically euthyroid with TSH/FT4/FT3 all well within the normal range. I attach an extract of the report and what little explanation came with it. It appears testing is oganised via http://www.thyroiduk.org.uk/tuk/testing/DIO2_test.html who are promoting the test. The analysis is seems to be carried out in a lab in Luxembourg. 

ThyroidUK state:

"If your report shows that you have inherited either one or both faulty genes, it may be worth taking your report, along with the research article, to your GP or endocrinologist and asking for a trial of T3 to be added to your levothyroxine."

The website references one paper in JCEM (http://jcem.endojournals.org/content/94/5/1623.full.pdf+html) which suggests "poorer psychologic well being" and "enhanced response to combined T4/T3 therapy" in patients with polymorphisms in the DIO2 gene.

Has anybody else come across this? Any help/advice/views much appreciated.

Stuart

Stuart Jones  | Principal clinical scientist
Clinical biochemistry / Pre-natal screening
King George Hospital
Barking, Havering and Redbridge University Hospitals NHS Trust
Barley Lane
Ilford
Essex
Technical lead | Lab Tests Online UK
http://www.labtestsonline.org.uk/

Barking, Havering & Redbridge University Hospitals NHS Trust: Working to make our hospitals better.

This communication, together with any files or attachments transmitted with

it contains information which is confidential and may be subject to legal

privilege and is intended solely for the use by the person(s) or entity to

whom it is addressed. If you are not the intended recipient you must not

copy, distribute, publish or take any action in reliance on it. If you have

received this communication in error, please notify

[log in to unmask] and delete it from your computer systems.

Barking, Havering & Redbridge University Hospitals NHS Trust reserves the

right to monitor all communications for lawful purposes. Receipt of this email

does not imply consent to use or provide this email address, or any others

contained therein, to any third party for any purposes. The contents of this

email are protected under international copyright law.

To save energy and paper please print this email only if you really need to.

_____________________________________________________________________________

This email has been scanned for viruses using antivirus software by

Barking, Havering & Redbridge University Hospitals NHS Trust. Whilst every

care is taken to avoid the transmission of virus code; please ensure that you

have up to date virus detection software before opening any E-mail

messages or attachments

______________________________________________________________________________