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Dear Experts, It is not uncommon to see some resting state components resulted from Melodic analysis indicating deactivation. I see that for the most part these areas have typical resting state attributes in that the frequency, normalized amplitude, and spatial distribution are in areas typically reported. But what does deactivation actually mean? Is it low signal compared to expected rs-fMRI signal level from the MRI? Is it inverse signal direction from "active" networks? Does it mean that a particular network is "off"? Thank you, Varina