As Juergen has mentioned, both the T200 and the BioRad ProteOn (XPR36) are good options (we have both).
The XPR36 is a higher throughput machine and can also be used for small molecule work (not quite as sensitive as the T200, but more sensitive than we had anticipated and certainly higher throughput).
Good luck,  tom

Tom Peat
Biophysics Group
CSIRO, CMSE
343 Royal Parade
Parkville, VIC, 3052
+613 9662 7304
+614 57 539 419
[log in to unmask]
From: CCP4 bulletin board [[log in to unmask]] on behalf of Bosch, Juergen [[log in to unmask]]
Sent: Tuesday, October 29, 2013 2:05 AM
To: [log in to unmask]
Subject: Re: [ccp4bb] Biacore/SPR

BiaCore 3000 or if you can afford the T200.
Proteon XPR36 would be a cheaper Option and should work as well.
Jürgen

On Oct 28, 2013, at 10:54 AM, Gang Dong wrote:

We mainly measure protein-protein interactions (sometimes protein-small molecules). Thanks! _Gang
 
From: Bosch, Juergen [mailto:[log in to unmask]] 
Sent: Monday, October 28, 2013 3:17 PM
To: Gang Dong
Cc: [log in to unmask]
Subject: Re: [ccp4bb] Biacore/SPR
 
Protein-protein interaction?
protein-small molecule interactions ?
Epitope mapping of mABs ?
Could you specify what you would like to do, as different models are good for different things.
Jürgen
 
On Oct 28, 2013, at 10:08 AM, Gang Dong wrote:


Dear all,
 
Could anyone tell me your experience with Biacore (any models) or a similar SPR-based technology for measuring interaction kinetics? I also want to know the price ranges to discuss with our department/facility managers.    
 
Thanks,
Gang
 
 
 
......................
Jürgen Bosch
Johns Hopkins University
Bloomberg School of Public Health
Department of Biochemistry & Molecular Biology
Johns Hopkins Malaria Research Institute
615 North Wolfe Street, W8708
Baltimore, MD 21205
Office: +1-410-614-4742
Lab:      +1-410-614-4894
Fax:      +1-410-955-2926
http://lupo.jhsph.edu




......................
Jürgen Bosch
Johns Hopkins University
Bloomberg School of Public Health
Department of Biochemistry & Molecular Biology
Johns Hopkins Malaria Research Institute
615 North Wolfe Street, W8708
Baltimore, MD 21205
Office: +1-410-614-4742
Lab:      +1-410-614-4894
Fax:      +1-410-955-2926
http://lupo.jhsph.edu