I once grew an oxymyoglobin crystal 1 cm long for neutron diffraction at Brookhaven. I was very proud of it, but when I got to Brookhaven I was told it was too big for the beam (!) so I had to use a much smaller one of only 8 mm**3 (Nature 292:81-82 (1981). I still have a few left over that look like 5-7 mm long (I just held a ruler up to the tube which is still on my office shelf)

Simon E.V. Phillips

Director, Research Complex at Harwell (RCaH)

Rutherford Appleton Laboratory

Harwell Oxford

Didcot

Oxon OX11 0FA

United Kingdom

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From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Tobias Beck
Sent: 24 October 2013 16:34
To: ccp4bb
Subject: [ccp4bb] largest protein crystal ever grown?

Dear all,

I was just wondering if anyone has some information or references about the dimensions of the largest protein crystal ever grown? I am aware that for neutron protein crystallography one usually needs crystals with mm dimensions. I have found some information on crystallization under micro-gravity and how this can enlarge the crystal size. However, I would rather be interested in the dimensions for crystals obtained from a regular lab setup.

Thanks, Tobias.

--
___________________________________________

Dr. Tobias Beck
ETH Zurich
Laboratory of Organic Chemistry
Wolfgang-Pauli-Str. 10, HCI F 322
8093 Zurich, Switzerland
phone: +41 44 632 68 65
fax: +41 44 632 14 86
web: http://www.protein.ethz.ch/people/tobias
___________________________________________

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