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You are invited to the following S3RI/IfLS special seminar: Genealogical inference in population genetics and the detection of natural selection. by Professor Mark Beaumont Abstract: It is now becoming feasible to sequence the genomes of many individuals. The pattern of variation within a sample of individuals is most easily described in terms of its genealogical and mutational history. In the absence of natural selection the shape of the genealogy varies across the genome in a predictable way that depends on the demographic history of the population. Selection yields genealogies and hence patterns of genetic variation that depart from expectations based on the demographic history. The genealogical, mutational, and demographic histories are unknown latent variables of very high dimension. The problem can be cast in a Bayesian framework but is intractable without approximation. This talk discusses various approaches that have been used for demographic inference, and then describes a methodology for detecting local adaptation using approximate Bayesian computation (ABC). Date: Thursday 14th November 2013 Venue: building 6 (Nuffield Theatre) room 1077, Highfield Campus, University of Southampton Time: The seminar starts at 3pm A drinks reception will be held afterwards. Please refer to the attached abstract and for the location map, please refer to the link below: http://www.southampton.ac.uk/visitus/campuses/highfield.html You may leave the list at any time by sending the command SIGNOFF allstat to [log in to unmask], leaving the subject line blank.