Dear Sophie,

The following is from the MEG guidelines paper http://www.fil.ion.ucl.ac.uk/spm/doc/papers/meeg_good_practice.pdf (p 361). You might want to read the rest of the stats chapter there for additional useful points.


Best,

Vladimir

Due to differential sensitivities of sensor and source space analyses it is sometimes the case that a particular effect is significant in one but
not the other. When an effect is significant at the sensor level with all the proper corrections for multiple comparisons and the hypothesis is about the existence of an effect rather than about a specific area
being involved, it could be acceptable to only report the peaks of a statistical map at the source level without requiring correction for multiple comparisons over the whole brain. When an effect is significant at
the source level corrected for multiple comparisons and the choice of time and frequency windows for the source analysis can be motivated a-priori, a sensor-level test is not necessary. What should be avoided
is doing a sensor-level test without proper MCP correction and using it to motivate a source-level test that achieves significance. This would constitute double-dipping (Kriegeskorte et al., 2009) similar to using peaks in the data to constrain a sensor-level test.





On Mon, Sep 30, 2013 at 1:07 PM, Sophie Galer <[log in to unmask]> wrote:
Hello Vladimir,

I have a little question regarding statistical significance in sensor
and source spaces and i hope you can help me.

How would you explain that a contrast between two conditions did not reach significance corrected for multiple comparaison in the sensor space whereas in the sources space it does?

Thank you very much for your help,

--
Sophie Galer - Ph.D. student
National Fund for Scientific Research (F.R.S - FNRS)
Université Libre de Bruxelles
LCFC-UR2NF
+322/555.42.98
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