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Hi, See the GLM help page that I linked to in your other message. It covers a wide variety of designs, including this one. Cheers, Jeanette On Thu, Sep 26, 2013 at 7:19 AM, Peng Syu-Jyun <[log in to unmask]>wrote: > Dear > > How can I create a design matrix using glm gui for correlating disease > age or duration with shape or intensity? > > Best regards > > Syu-Jyun > >