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Dear colleagues, I hope this will not be construed as self-promotion, but we would like to draw your attention to the following paper, we just published: Djulbegovic B, Kumar A, Glasziou P, Miladinovic B, Chalmers I. Trial unpredictability yields predictable therapy gains. Nature 2013;500:395-396 http://www.nature.com/nature/journal/v500/n7463/full/500395a.html We think the results and principles described in the paper should be a part of core EBM. Thanks ben