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Dear all We have been trying to run pointless on a large mtz file which seems to be allocating more than 1.5Gb of memory resulting in the following error: The program run with command: /Applications/ccp4-6.3.0/bin/pointless has failed with error message pointless(507) malloc: *** mmap(size=1577435136) failed (error code=12) *** error: can't allocate region *** set a breakpoint in malloc_error_break to debug We are using OSX 10.8.4 and believe that we need a 64bit version of pointless. Looking at the pre release ftp site, we found the latest versions of pointless compiled for OSX 10.8, however they do not run. dyld: Symbol not found: __ZNSt11range_errorD1Ev Referenced from: /Applications/ccp4-6.3.0/bin/pointless-1.8.7.osx10.8 Expected in: /usr/lib/libstdc++.6.dylib in /Applications/ccp4-6.3.0/bin/pointless-1.8.7.osx10.8 Any help would be greatly appreciated (and any know if there is a upcoming release of a pre-compiled CCP4 OSX-64bit??) Regards Sheena SHEENA McGOWAN | ARC Future Fellow Department of Biochemistry and Molecular Biology MONASH UNIVERSITY Rm 243, Building 77, Wellington Rd, Clayton Victoria, AUSTRALIA 3800 T + 61 3 9902 9309 | F + 61 3 9902 9500 E [log in to unmask] | Skype s.mcgowan W http://www.med.monash.edu.au/biochem/staff/mcgowan.html Australian Society for Biochemistry and Molecular Biology (State Representative) http://www.asbmb.org.au/ 39th Lorne Conference for Protein Structure and Function http://www.lorneproteins.org February 9-13, 2014. Mantra Lorne, Lorne, AUSTRALIA