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Postdoctoral Research Position Identification of a novel metabolic regulator of AMPK Astrazeneca, Alderley Park, England Application Procedure: For full details and application please visit: http://gs.globalsuccessor.com/fe/tpl_astrazenecav2.asp?newms=jj&id=59972 Post Summary: Applications for a Post-Doctoral position in structure and biophysics primarily located at Astrazeneca in Alderley Park, Cheshire, England are invited. AMPK (AMP activated Kinase) is a key regulator of adenine nucleotide levels and has been implicated as a target in a number of diseases in diabetes, oncology and neuroscience. Our goal is to continue development and use biophysical and structural tools to characterize metabolites that regulate AMPK. We aim to use these studies to identify a putative novel metabolic regulator and further improve understanding of the mechanisms controlling AMPK activity. Person Specification: The candidate should have a Ph.D. in protein engineering (ie. construct design, molecular biology, protein expression and purification) and either protein biophysics or protein crystallography. Academic Supervisor: Steve Gamblin is acting as the academic supervisor. The work is part of an on-going collaboration between Astrazeneca and Prof. Steve Gamblin and Prof. Dave Carling from the MRC. (Carling et al. Biochem. J. 2012, Xiao et al, Nature 2011, Xiao et al, Nature 2007). Closing Date: 27th August 2013 Jon Read Associate Principal Scientist _____________________________________________________________________ Astrazeneca R&D, Decs, Astrazeneca, Mereside, Alderley Park, Cheshire, SK10 4TG UK Tel +44 (0)1625 510661 Mobile +44 (0)7775 040376 From: Read, Jon Sent: 26 June 2013 01:08 To: Read, Jon Subject: AMPK Post-Doc Advert Astrazeneca is inviting applications for a Post-Doctoral position in structure and biophysics titled: Identification of a novel metabolic regulator of AMPK. The applicant's PhD or Post-Doctoral studies should include substantial experience in biophysics, protein crystallography or related fields and preference will be given to demonstrated experience in molecular biology and protein expression. Job description: The main purpose of the work is to characterize the interaction of AMPK with compounds which regulate the activity of AMPK. Biophysical and crystallographic studies, will be performed, in the structural and biophysical laboratories of Astrazeneca. Additional studies will be carried out in the laboratories of Prof. Steve Gamblin (URL). The work is part of an on-going collaboration with Prof. Steve Gamblin and Prof. Dave Carling from MRC. (Carling et al. Biochem. J. 2012 Xiao et al, Nature 2011, Xiao et al, Nature 2007) Deadline for application: 15 July 2013 Applications should include: Curriculum Vitae, names and 2 references sent to Dr Jon Read, [log in to unmask] Please go to the following website to find about further details on this application and project: Link to AZ careers site. Jon Read Associate Principal Scientist _____________________________________________________________________ Astrazeneca R&D, Decs, Astrazeneca, Mereside, Alderley Park, Cheshire, SK10 4TG UK Tel +44 (0)1625 510661 Mobile +44 (0)7775 040376 -------------------------------------------------------------------------- AstraZeneca UK Limited is a company incorporated in England and Wales with registered number: 03674842 and a registered office at 2 Kingdom Street, London, W2 6BD. Confidentiality Notice: This message is private and may contain confidential, proprietary and legally privileged information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorised use or disclosure of the contents of this message is not permitted and may be unlawful. Disclaimer: Email messages may be subject to delays, interception, non-delivery and unauthorised alterations. Therefore, information expressed in this message is not given or endorsed by AstraZeneca UK Limited unless otherwise notified by an authorised representative independent of this message. No contractual relationship is created by this message by any person unless specifically indicated by agreement in writing other than email. Monitoring: AstraZeneca UK Limited may monitor email traffic data and content for the purposes of the prevention and detection of crime, ensuring the security of our computer systems and checking Compliance with our Code of Conduct and Policies.