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Hello N., > I’m working on a study with children (10-16 years) and I would like to > performed a ROI analysis on my data. Since there is no predefine ROIs > for children (as for example the Anatomy toolbox ROIs for adults) and I > don’t have the capacity to performed anatomical ROIs by my own, I would > like to use ROIs based on adult brains (in MNI) for my analyses. I used > the TOM-toolbox to developed TPMs and enter these in “NewSegment” to > perform the segmentation. Is it possible to use the parameters I > obtained from this step to convert the ROIs in MNI space into the space > of the TPMs, I’ve build with the TOM-toolbox? I do not understand exactly what you mean by that but for transforming an already normalized region of interest into the space of the TOM tpm, the individual spatial normalization parameters will not help you. What you could do is something along the lines of the procedure we did some years ago (Wilke et al., 2003, PMID 14527581), i.e., take an "adult" ROI and use a non-linear transformation to bring it into your pediatric TPM space. I would suggest to use ROIs that are not very small, and potentially smooth them slightly. Alternatively, you could derive a region of interest from a statistical analysis on your own data (i.e., a cluster from a VBM or fMRI study), which would also alleviate the problem. > I also saw that based on the NIHPD some templates were developed for > children. If I understand it correct these templates are in MNI space. > Would it better to use these templates or the procedure I described above? I would naturally argue to use TOM :) but either way, the procedures described above would work in both cases. > For your help I thank you in advance. You're welcome :) Cheers, Marko -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn/ ____________________________________________________