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Hi, 

Thank you for your speedy response. So all the L2 models in which this issue arises have in common a design comparing copes across different L1 runs. All are specified as fixed effects. Below are some examples:

1) 

Input images: input 1 (run1, cope4.nii.gz), inputs 2-7 (runs 3-8, cope1.nii.gz)
EV matrix: identity matrix where each cope image input is a separate EV (e.g. EV1 = input 1)
Contrast matrix: 
C1, EV1 =-6.0, EVs 2-7 = 1.0 (each)
C2, EV1 = 6.0, EVs 2-7 = -1.0 (each)


2) 

Input images: input 1 (cope1.feat, from L2 average of L1 cope1.feat from runs 3-5)
                       input 2 (cope1.feat, from L2 average of L1 cope1.feat from runs 6-8)
EV matrix: EV1 = Input 1, EV2 = Input 2
Contrast matrix:
C1, EV1 = 1, EV2 = -1
C2, EV1 = -1, EV2 = 1

*I should note that there is no extreme smoothness in any L2 solely averaging across runs.

3) 

Input images: inputs 1-6 (cope1.nii.gz, runs 3-8)
EV matrix:  identity matrix where each cope image input is a separate EV (e.g. EV1 = input 1)
Contrast matrix:
C1, EVs 1-3 = 1.0 (each), EVs 4-6 = -1.0 (each)
C2, EVs 1-3 = -1.0 (each), EVs 4-6 = 1.0 (each)

How do these seem?

Many thanks,
Micah