Hi - yes it is fine and common to see a group difference outside of the group average.

Cheers.

--------------------

Stephen M. Smith, Professor of Biomedical Engineering

Associate Director, Oxford University FMRIB Centre

FMRIB, JR Hospital, Headington,

Oxford. OX3 9 DU, UK

+44 (0) 1865 222726 (fax 222717)

[log in to unmask]

http://www.fmrib.ox.ac.uk/~steve

----------------------

On 19 Jul 2013, at 11:35, Helen Sawaya <[log in to unmask]> wrote:

Dear experts,

I have a question regarding the plausability of my results. I am running Flame 1 to test group difference on functional connectivity maps. I got a robust group difference in a cluster that does not overlay either group's mean connectivity map. The cluster is not in white matter or CSF regions either. I'm wondering how possible it is to get a group difference in a large cluster (around 1000 voxels) , even though the groups' maps (thresholded and unthresholded) only cover a small part of the cluster.

Thank you!

Helen