Mike Steiner asked if abetalipoproteinaemia would have an impact on the electrophoretic pattern of the serum using either cellulose actetate or a capillary technique ?

 

In my experience beta-lipoprotein (LDL) used to be seen as a very narrow, rather intense, „squiggly (not straight)“ line usually between alpha-2 and beta on most serum protein electrophoreses using agarose. This was when we used Beckman system. It did not contribute much to the densitometer scan. Since we changed to Helena a number of years ago, the LDL band does not seem as apparent. In fact, I just looked at a couple of gels and could not see any band that looked like LDL.  The difference is most probably a difference in the stain.

 

So abetalipoproteinemia probably would have little or no impact. (I have no experience with capellary electrophoresis.)

 

-Jim