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Hi RiK, This is very useful.. Thanks very much... I would like to take your, and others, opinion about this: My main aim is to get the highest possible activations but at the same time I can not use block designs because subjects cannot perform it accurately. Would this design be the optimal one: ISI = 7s + or - 1.5 s Also I have three conditions : squeezing at different ( 3 ) forces. I took this from a previous study. Thanks AS On Fri, Jun 7, 2013 at 10:11 AM, Rik Henson <[log in to unmask]>wrote: > > > Is there any available toolbox/software that helps optimizing paradigms? > > Are their any specific rules that I should follow. Most papers say in a > random and counterbalancing way. > > This might be a good start: > > http://imaging.mrc-cbu.cam.ac.uk/imaging/DesignEfficiency (general > advice about how to optimise an fMRI experiment) > > > and here are some tools: > > http://surfer.nmr.mgh.harvard.edu/optseq/ (tool for optimising > randomised designs) > > http://psych.colorado.edu/~tor/Software/genetic_algorithms.html(genetic algorithm for optimising fMRI designs) > > http://www.cabiatl.com/CABI/resources/fmrisim/ (tool for simulating > fMRI designs) > > > plus you can also find a Matlab function called fMRI_GLM_efficiency.m that > I have just put here: > > http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal/analysis/ > > > BW,R > > ------------------------------------------------------- > Professor Richard Henson > Assistant Director for Neuroimaging > MRC Cognition & Brain Sciences Unit > 15 Chaucer Road > Cambridge, CB2 7EF > England > EMAIL: [log in to unmask] > URL: http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal > TEL +44 (0)1223 355 294 x501 > FAX +44 (0)1223 359 062 > MOB +44 (0)794 1377 345 > ------------------------------------------------------- > > ________________________________________ > From: SPM (Statistical Parametric Mapping) [[log in to unmask]] on behalf > of fMRI [[log in to unmask]] > Sent: 07 June 2013 09:15 > To: [log in to unmask] > Subject: [SPM] Event onset randomization and jittering > > Hi all, > > Is there any available toolbox/software that helps optimizing paradigms? > > Are their any specific rules that I should follow. Most papers say in a > random and counterbalancing way. > > > Thanks > > AS >