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Hi Jay What I meant by "using tractography for inter-subject registration" is not quite the same as running nonlinear reg per se. Rather, I meant using tractography as a guide for defining regions of interest in white matter that are aligned across subjects. Cheers, Saad On 18 Jun 2013, at 18:35, Stamatios Sotiropoulos <[log in to unmask]> wrote: > Hi Jay > > There is currently no tool to perform tractography-based registration. In the future, connectivity-based multimodal registration will be supported, if you want to learn more you can have a look at a recent paper to appear at IPMI 2013: > > Robinson et al, Multimodal Surface Matching: Fast and Generalisable Cortical Registration using Discrete Optimisation > > Cheers > Stam > > > On 18 Jun 2013, at 10:41, SUBSCRIBE FSL Jay wrote: > >> Hello Saad, >> >> Thank you for your suggestion. >> But how can I use tractography as a guide for cross-subject "registration"? Normally, i calculate the non-linear registrations (for each subject separately) and provide them as an input to probtrackx2 routine. I do not know how to do it the other way around (i.e use tractography to guide cross-subject registration). I did not find an option (or advanced option) for this on the FDT registration tab. >> >> Can you please explain this in more detail? >> Thank you >> Jay >> > -- Saad Jbabdi University of Oxford, FMRIB Centre JR Hospital, Headington, OX3 9DU, UK (+44)1865-222466 (fax 717) www.ndcn.ox.ac.uk/team/researchers/saad-jbabdi