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Hi Jake, 1. Almost certainly not independent, but it doesn't matter, because there is no need to assume independence with randomise. The spatial dependence, if any, is taken into account implicitly. 2. They aren't stringent, they are correct. These are the values that should be used in general, and this a recommendation. All the best! Anderson 2013/5/29 Jake <[log in to unmask]> > Dear Saad and FSL, > > I was wondering if you can help me with what might be basic learning > questions, but after reading the boards and the FSL documentation it's > still confusing to me. I've been researching the type of correction I > should use for the outputs of randomise, using probtrackx data. (Study > design is tractography comparison between two groups.) > > I'm wanting to correct my stats for multiple comparisons but two things > are on my mind: > > 1- are voxels really independent? (does it matter, and are conventional > MRI corrections appropriate?) > 2- the "corrp" stat output from randomise seem stringent.. How do you > recommend I should correct? > > I seem to be getting high raw t-stats but am unsure how to procede.... > > Thanks in advance for your time and help!!! > > Best, > Jake >