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Surely one should use Total Calcium. That's what's there and that's what's being cleared. Corrected/adjusted calcium doesn't exist - it's only an idea in the mind of an ideal Albumin,(i.e.what would - or might - be there if the albumin were higher than it actually is) so it can't be used in the clearance calculation. Michael -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of David Wright Sent: 17 June 2013 16:09 To: [log in to unmask] Subject: Calcium Creatinine Clearance Ratio, CCCR Calcium Creatinine Clearance Ratio is used in the diagnosis of FHH. Currently setting up parameters on the Host computer to make CCCR available. A question to ponder.... Formula (e.g. Hammersmith) appear to use Serum Calcium and not Adjusted Calcium (Pathology Harmonization) in CCCR calculations. Does using Adj Ca make a significant difference? Does using Adj Ca introduce more error into the calculation (various formulae for Adj Ca) or reduce a potential error (low or elevated albumin levels). Thanks David Wright Lead BMS. Antrim ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ Great Western Hospitals NHS Foundation Trust Great Western Hospital Marlborough Road Swindon SN3 6BB Tel 01793 60 40 20 http://www.gwh.nhs.uk Register to become a member of the Trust at https://members.gwh.nhs.uk This message and any files transmitted with it are confidential and intended solely for the individual(s) addressed. If you believe you have received this e-mail in error, disclosing, copying, distributing or retaining this message, or any part of it, is strictly prohibited; please notify the sender immediately and delete it from your system. Any views or opinions presented are solely those of the author and do not necessarily represent those of Great Western Hospitals NHS Foundation Trust. All messages sent by the Trust are checked for viruses but this does not, and cannot, guarantee that a virus has not been transmitted. The Trust accepts no liability for any damage caused by any virus transmitted with this e-mail. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/