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Hi I suspect this will be covered in More or Less, the BBC radio programme next week. The programme looks at statistics in the news and is available as a podcast on http://www.bbc.co.uk/podcasts/series/moreorless Best wishes Fiona Morgan From: Susan Fowler <[log in to unmask]> To: [log in to unmask] Date: 16/05/2013 15:38 Subject: Fwd: Angelina Jolie's 87% Risk Sent by: "Evidence based health (EBH)" <[log in to unmask]> In case you are wondering or have people asking you (as I did) where that 87% increased risk number that Angelina mentions in her NY Times editorial came from, I believe this is it... U.S. Preventive Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility; 2005. "These mutations increase a woman's lifetime risk for breast cancer to 60% to 85%..." · Brose MS, Rebbeck TR, Calzone KA, Stopfer JE, Nathanson KL, Weber BL. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. J Natl Cancer Inst 2002;94:1365-72. · Thompson D, Easton DF. Cancer incidence in BRCA1 mutation carriers. J Natl Cancer Inst 2002;94:1358-65. Of course, I could be mistaken, so if someone has something better please share! -- Susan Fowler, MLIS Medical Librarian Evidence at Becker: http://beckerguides.wustl.edu/ebm Systematic Reviews Guide: http://beckerguides.wustl.edu/SystematicReviews Becker Medical Library, Washington University in St. Louis 314-362-8092 [log in to unmask]