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Hi Anders, You can use fslmeants with the --showall option and enter the one 3D volume as a mask. Hope that helps! Elizabeth On Apr 21, 2013, at 11:01 PM, Anders Eklund wrote: > Dear experts, > > is there any FSL function that calculates the mutual information between two volumes? Or even better, is there any function that takes one volume and one 4D dataset and returns a timeseries with the mutual information for each timepoint? > > cheers, > Anders