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Hi - not the virtual machine should be OK. You need to look carefully at all input and output images involved here - including checking full range of values with fslstats IMAGE -R Steve. On 19 Apr 2013, at 05:00, Armin Biller <[log in to unmask]> wrote: > hi steve, > > that's what worries me most: the input images include positive values only. i run fsl on a virtual box based linux. is that a problem? > > thx! > armin > > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------