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Dear experts I am running fsl_regfilt on individual preprocessed functional images to regress motion spikes and white matter signal. I want to use this output in group ICA and then dual regression. I was wondering if the design matrix in fsl_regfilt should include a column of 1s before the columns representing the confounds and then use -f " " to regress the confounds. (example column of 1s, column of motion spikes, column of white matter signal, then use -f "2,3") 1 0 10050.9 1 0 10037.6 1 0 10025.1 1 0 10037.8 1 0 10049 1 1 10051 1 0 10051.4 1 0 10053.7 I created a design without the column of ones and had a great deal of white matter signal in my melodic components so I'm wondering if I did not properly regress out the white matter signal from the filtered functional image. Thank you!!! Helen