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Hi, I don't think I understand your question. The contrast you specified is the contrast for comparing the groups. You would run [1 -1] to test males>females and [-1 1] for females<males. Cheers, Jeanette On Fri, Apr 12, 2013 at 3:41 AM, SUBSCRIBE FSL Mariam Zabihi < [log in to unmask]> wrote: > Dear Jeanette, Thank you for your useful comment. I will really appreciate > if you answer the following question. > Since I'm really interested to investigate the difference of two group, > Can I define the contrasts like this?[1 0],[0 1] and then find the > significant pvalues for each of them separately and remove the common > pvalues' index, then consider the rest of each pvalues as effect of male or > female? Does it seem reasonable way to find the difference of two group? > Mariam >