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Dear Lists: I am planning to do a systematic review of intervention studies about diabetes medications, but I am not sure which critical appraisal tool is best (in terms of validity and reliability) to use to appraise therapy and/or intervention trials. I am aware of this article: A systematic review of the content of critical appraisal tools, by Katrak et al, which explained the different tools, I guess >120 tools in literature, however, I am still not sure which one to use? I would be grateful for your feedback... Samia Dr. Samia Alhabib, MD, PhD