Dear Karsten,
Thanks for quick reply. The processing procedure of CBF data are: Firstly, the CBF image were corregistered with the corresponding T1 image;Secondly,the T1 image were normalized using the unified segmentation method in SPM;Finally,the CBF images were spatially normalized and re-sampled (2x2x2 mm) using the normalization parameters estimated during unified segmentation.
The 3D ASL sequence I used constructed images of two types: one is perfusion-weighted image and the other is PD image.Thanks for you suggestion and I will try a normalization on the PD image.
Best,
Bin-Ke
2013/3/4 Karsten Specht
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Dear Bin-Ke,
Which template have you used? You wrote you did a coregistration before. Did you coregister the ASL images with an T1 image and segmented this one or what exactly was your procedure?
You could also try to normalize the CBF maps to a PET template and create your own population based template out of that and re-normalize your scans. Some ASL sequences are providing also a PD image. You may want to try out a normalization on that one, as well.
Good luck,
Karsten
Dear all:
I used unified segmentation to perform normalization of my CBF images and found the normalization effect was bad (images of unnormalized and normalized were attached). I have done the corregister before normalization.
The pulse sequence of ASL are 3DASL (no contrast,GE healthcare MR-750 3.0 T scanner) and the CBF images were got using the 3DASL functiontool of the scanner.
Any suggestion / advice will be very welcome.
Many thanks in advance,
Bin-Ke