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Dear Karsten, Thanks for quick reply. The processing procedure of CBF data are: Firstly, the CBF image were corregistered with the corresponding T1 image;Secondly,the T1 image were normalized using the unified segmentation method in SPM;Finally,the CBF images were spatially normalized and re-sampled (2x2x2 mm) using the normalization parameters estimated during unified segmentation. The 3D ASL sequence I used constructed images of two types: one is perfusion-weighted image and the other is PD image.Thanks for you suggestion and I will try a normalization on the PD image. Best, Bin-Ke 2013/3/4 Karsten Specht <[log in to unmask]> > Dear Bin-Ke, > > Which template have you used? You wrote you did a coregistration before. > Did you coregister the ASL images with an T1 image and segmented this one > or what exactly was your procedure? > > You could also try to normalize the CBF maps to a PET template and create > your own population based template out of that and re-normalize your scans. > Some ASL sequences are providing also a PD image. You may want to try out a > normalization on that one, as well. > > Good luck, > > Karsten > > > Fra: Bin-Ke YUAN <[log in to unmask]> > Svar til: Bin-Ke YUAN <[log in to unmask]> > Dato: 10Montag, 4. März 2013 11:51 > Til: <[log in to unmask]> > Emne: [SPM] Normalization of ASL images > > Dear all: > I used unified segmentation to perform normalization of my CBF images and > found the normalization effect was bad (images of unnormalized and > normalized were attached). I have done the corregister before normalization. > The pulse sequence of ASL are 3DASL (no contrast,GE healthcare MR-750 3.0 > T scanner) and the CBF images were got using the 3DASL functiontool of the > scanner. > Any suggestion / advice will be very welcome. > > Many thanks in advance, > Bin-Ke >