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SPMers, Any inherent problems or issues associated with performing 1st level analyses in native space and then warping the resulting .con images with either standard normalization or DARTEL method? On a related note, would this type of processing scenario cause a problem with GIFT or MANCOVAN? I have longitudinal data (baseline, 6wk, 1yr) and thought it might be nice to retain the subjects' data in native space for time x variable analyses on an individual level for visualization, but then take their .con images into MNI space for group x time x variable comparisons. Thanks, Jeff ----------------------------------------------------------------------- Jeff Browndyke, Ph.D. Clinical & Research Neuropsychologist Durham VA & Duke University Medical Centers [log in to unmask] / [log in to unmask] office: (919) 286-0411 ext. 4656 cell: (336) 264-4222