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Check the initial alignment between the images (Check Reg). I'd expect the plots to look like this if there is zero overlap between the images. Bets regards, -John On 24 March 2013 18:50, shiliang huang <[log in to unmask]> wrote: > Dear Experter > > I want to use SPM to do coregister. I imported the reference image and the > source image and the image series. It gave the following figure during it > was runing. It seems like giving out different figure compared before. > What is the reason? >