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Hi Eugene, thanks a lot for your response. Yes, this makes perfect sense. Cheers, Andreas Von: Eugene Duff <[log in to unmask]> Antworten an: FSL - FMRIB's Software Library <[log in to unmask]> Datum: Sonntag, 17. März 2013 23:36 An: <[log in to unmask]> Betreff: Re: [FSL] mean activation for Feat's higher level, paired t-test example Hi Andreas You can define subject mean contrasts and take them up into a third-level analysis, like the Multi-Session & Multi-Subject (Repeated Measures - Three Level Analysis) example. I think this should be OK as long as the other regressors at the 2nd level are orthogonal to the means. Cheers, Eugene On 17 March 2013 22:11, Andreas Bartsch <[log in to unmask]> wrote: > I want to get the mean activation across two conditions. The paired --