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Hi I'd just integrate them individually with Mosflm, then merge the two MTZ files into one with Pointless(*), then scale with Aimless. (*) pointless hklin first.mtz second.mtz hklout pointless.mtz aimless hklin pointless.mtz hklout aimless.mtz should do the trick - pointless even works with a wild card if you have many mtz files to merge (not sure how many "many" can be, but it's certainly a lot more than 10), e.g. pointless hklin part_*.mtz hklout pointless.mtz Dead easy with normal CCP4 programs, RTM for pointless for further details. You can even do this in ccp4i *really easily*! On 28 Mar 2013, at Thu28 Mar 10:08, S. Thiyagarajan wrote: > Dear all > I have two data sets, 75 frames each from crystals of the same > protein - same cell parameters/space group (P4). > I could process them seperately each yielding > 90% completeness > but with poor multiplicity ( < 2 ) > > If I merge the data sets using CAD, I loose the data reduction > statistics of the combined data set. > > I do not have HKL2000. > > Which (free) tool can handle two different diffraction data sets, > process them together to give a single final data statistics. > > Thanks and regards > Thiyaga > > > > S. Thiyagarajan > Centre of Excellence in Bioinformatics > School of Biotechnology > Madurai Kamaraj University > Madurai - 625021 > Ph: +91-9159224881 (cell) Harry -- ** note change of address ** Dr Harry Powell, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH Chairman of European Crystallographic Association SIG9 (Crystallographic Computing)