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Hi - My opinion on this is that the TBSS approach is good for the bulk of white matter (which is what TBSS is all about), but sub-optimal near the cortex, where you may want to have your seed ROIs. Therefore, the FDT default favours using a T1-weighted structural to drive nonlinear registration to MNI space, ideally with a good distortion correction of the diffusion data. Cheers Saad On 6 Feb 2013, at 21:26, Marenco, Stefano (NIH/NIMH) [E] wrote: > I was wondering why the FNIRT transform from diffusion to standard space that is considered optimal for TBSS is not used as a default in bedpostx. Has anyone compared the two for tractography results? > > Stefano Marenco, MD > NIMH/CBDB > 10 Center Drive, Bldg 10 room 3C103 > Bethesda MD 20892 > Tel 301 435-8964 > Fax 301 480-7795 > Email: [log in to unmask] > -- Saad Jbabdi University of Oxford, FMRIB Centre JR Hospital, Headington, OX3 9DU, UK (+44)1865-222466 (fax 717) www.fmrib.ox.ac.uk/~saad