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Thank you Manfred, To be honest I have tried to understand the Pearson linear CC since reading the nature crystallography methods paper by Karplus and diederichs, but I am having trouble. I do not clearly understand what it represents. Do you know any good resources that could help me out? -Yarrow > > If you have two sets of numbers which correspond ideally, > you should calculate a correlation coefficient, to be precise > a Pearson linear CC. This is independent of scaling. > > If you want to compare mutant vs native, you probably > have to calculate residue average B-factors, because > you won't have the exact same number of atoms. > > Best, Manfred > > On 25.02.2013 21:08, Yarrow Madrona wrote: >> Hello, >> >> Does anyone know a good method to compare B-factors between structures? >> I >> would like to compare mutants to a wild-type structure. >> >> For example, structure2 has a higher B-factor for residue X but how can >> I >> show that this is significant if the average B-factor is also higher? >> Thank you for your help. >> >> > > -- > Dr. Manfred. S. Weiss > Helmholtz-Zentrum Berlin für Materialien und Energie > Macromolecular Crystallography (HZB-MX) > Albert-Einstein-Str. 15 > D-12489 Berlin > GERMANY > Fon: +49-30-806213149 > Fax: +49-30-806214975 > Web: http://www.helmholtz-berlin.de/bessy-mx > Email: [log in to unmask] > > > ________________________________ > > Helmholtz-Zentrum Berlin für Materialien und Energie GmbH > > Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher > Forschungszentren e.V. > > Aufsichtsrat: Vorsitzender Prof. Dr. Dr. h.c. mult. Joachim Treusch, stv. > Vorsitzende Dr. Beatrix Vierkorn-Rudolph > Geschäftsführung: Prof. Dr. Anke Rita Kaysser-Pyzalla, Thomas Frederking > > Sitz Berlin, AG Charlottenburg, 89 HRB 5583 > > Postadresse: > Hahn-Meitner-Platz 1 > D-14109 Berlin > > http://www.helmholtz-berlin.de > > -- Yarrow Madrona Graduate Student Molecular Biology and Biochemistry Dept. University of California, Irvine Natural Sciences I, Rm 2403 Irvine, CA 92697