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Position: Group Leader– Structural Biology – Protein Chemistry Client: Dart NeuroScience LLC (DNS) is a privately held Delaware Limited Liability Company with offices in San Diego, CA. DNS will discover new technologies and develop new therapies to help maintain cognitive vitality throughout life. www.dartneuroscience.com DNS is seeking a group leader with extensive experience in the development and implementation of protein purification processes for macromolecular crystallography studies. Reporting to the director of structural biology, the successful candidate will be responsible to establish and manage the protein purification team within the group. The candidate should have excellent knowledge of the state-of-the-art protein purification equipment and processes necessary to create and mentor others in establishing purification procedures that reproducibly lead to the generation of crystallization-grade protein in quantity and quality suitable for structural studies. Major responsibilities will include independent hands-on experimental work and leading a team of scientists and research associates to support large scale protein purifications of proteins recombinantly expressed in either prokaryotic or eukaryotic (baculovirus and mammalian cells) systems and originating from different protein families including membrane proteins. The candidate will be required to provide scientific expert advice to group members and have frequent interactions with the molecular biologists, protein production facility and crystallographers in the group. The candidate will be required to provide feedback to team members to maximize protein yields and quality that will lead to successful crystallization enabling 3D structure determination. Good communication skills, leadership skills, project and sample management experience overseeing multiple projects in parallel as well as capacity for strategic thinking are required. Requirements & Responsibilities: · Ph.D. in life science with thesis. · 8+ years of relevant experience in protein purification and biophysical characterization of proteins originating from different protein families for crystallization and 3D-structure determination. · Preferably 1+ year of industrial supervisory experience of Ph.D. scientists and research associates. · Proven hands-on experience in different protein purification methods (e.g. affinity, size-exclusion, ion-exchange, isoelectric focusing chromatography) and biochemical/biophysical characterization techniques (e.g., Western blot, light scattering, calorimetry, analytical ultracentrifugation, DLS, thermal melting, protein MS, protein NMR). · Expert knowledge in the scientific principles and concepts of protein chemistry and good understanding of the protein quality requirements for crystallization purposes preferably demonstrated through peer-reviewed publications. · Knowledge in membrane protein chemistry and other areas of structural biology (molecular biology and crystallography) is desirable. · Inter-disciplinary knowledge of drug discovery (enzymology, cellular pharmacology, DMPK) is a plus. · Demonstrated independent thought/creativity in science. Excellent collaboration, communication (oral and written) and multitasking skills and able to present work formally to Scientific Research Committees. Opportunity: DNS offers competitive salaries and a great benefits package including incentive bonuses, healthcare, vision, dental, long-term disability, life insurance and a 401(k) retirement savings plan.For Additional Information Contact: Bill Domann Cell: 415 726 9704 Office: 858 756 227 Email: [log in to unmask] Jovanna Bost Market Development & Business Relations The Domann Organization-Life Science Leadership Retained Search Services since 1988 www.domann.net [log in to unmask] 415 .726.9705